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A randomised,double-blind,placebo-controlled study of L-throsine was done in ten subjects with narcolepsy and cataplexy.Of twenty-eight visual analogue scales rating mood and arousal,the subjects'ratings in the tyrosine treatment(9 g daily)and placebo periods differed significantly for only three(less tired,less drowsy,more alert).Ratings of daytime drowsiness,cataplexy,sleep paralysis,night-time sleep,overall clinical response,and measurements of multiple sleep latency and tests of speed and attention did not differ significantly between tyrosine and placebo periods.Dietary supplementation with tyrosine 9 g daily for 4 weeks seems to have a mild stimulant action on the central nervous system but this effect is not clinically significant in the treatment of the narcoleptic syndrome. |
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